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PMAIP1

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GENERAL INFORMATION

Gene name

 PMAIP1

Gene description

 Phorbol-12-myristate-13-acetate-induced protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (U-138 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA051063
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051063 HEK 293 No staining    
HPA051063 U-2 OS Vesicles
HPA051063 U-251 MG No staining    

GENE INFORMATION

Gene name

 PMAIP1 (HGNC Symbol)

Synonyms

 APR, NOXA

Description

 Phorbol-12-myristate-13-acetate-induced protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 18

Cytoband

 q21.32

Chromosome location (bp)

 59899948 - 59904306

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141682 (version 83.38)

Entrez gene

 5366

UniProt

 Q13794 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13794

Antibodypedia

 PMAIP1 antibodies

PROTEIN BROWSER
PMAIP1-001
PMAIP1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PMAIP1-001
ENSP00000326119
ENST00000316660
Q13794 [Direct mapping]
Phorbol-12-myristate-13-acetate-induced protein 1
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Predicted intracellular proteins
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GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0009411 [response to UV]
GO:0010165 [response to X-ray]
GO:0010498 [proteasomal protein catabolic process]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0012501 [programmed cell death]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0043029 [T cell homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043331 [response to dsRNA]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0051607 [defense response to virus]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0071456 [cellular response to hypoxia]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
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 54 aa
6 kDa 		No 0
PMAIP1-002
ENSP00000269518
ENST00000269518
Q13794 [Direct mapping]
Phorbol-12-myristate-13-acetate-induced protein 1
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Predicted intracellular proteins
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0010498 [proteasomal protein catabolic process]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0012501 [programmed cell death]
GO:0032461 [positive regulation of protein oligomerization]
GO:0042149 [cellular response to glucose starvation]
GO:0043029 [T cell homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043331 [response to dsRNA]
GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0051607 [defense response to virus]
GO:0071456 [cellular response to hypoxia]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0072593 [reactive oxygen species metabolic process]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 136 aa
15 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.