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SIRT3

CANCER ATLAS

Gene description

 Sirtuin 3

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA026809
CAB037142

GENE INFORMATION

Gene name

 SIRT3 (HGNC Symbol)

Synonyms

 SIR2L3

Description

 Sirtuin 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 215458 - 236931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142082 (version 83.38)

Entrez gene

 23410

UniProt

 Q9NTG7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NTG7

Antibodypedia

 SIRT3 antibodies

PROTEIN BROWSER
SIRT3-001
SIRT3-002
SIRT3-003
SIRT3-004
SIRT3-008
SIRT3-009
SIRT3-010
SIRT3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIRT3-001
ENSP00000372191
ENST00000382743
Q9NTG7 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006476 [protein deacetylation]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0009060 [aerobic respiration]
GO:0016020 [membrane]
GO:0016787 [hydrolase activity]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0051287 [NAD binding]
GO:0070403 [NAD+ binding]
GO:0070932 [histone H3 deacetylation]
GO:2000757 [negative regulation of peptidyl-lysine acetylation]
Show all
 399 aa
43.6 kDa 		No 0
SIRT3-002
ENSP00000432937
ENST00000524564
E9PN58 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0051287 [NAD binding]
GO:0070403 [NAD+ binding]
Show all
 353 aa
39.2 kDa 		No 0
SIRT3-003
ENSP00000435464
ENST00000525319
E9PK80 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006476 [protein deacetylation]
GO:0008270 [zinc ion binding]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0051287 [NAD binding]
GO:0070403 [NAD+ binding]
Show all
 318 aa
35.1 kDa 		No 0
SIRT3-004
ENSP00000433077
ENST00000532956
E9PM75 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
 345 aa
37.6 kDa 		No 0
SIRT3-008
ENSP00000437216
ENST00000529382
Q9NTG7 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006476 [protein deacetylation]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0009060 [aerobic respiration]
GO:0016787 [hydrolase activity]
GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0051287 [NAD binding]
GO:0070403 [NAD+ binding]
Show all
 257 aa
28.6 kDa 		No 0
SIRT3-009
ENSP00000432857
ENST00000528469
E9PNA0 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
 93 aa
10.7 kDa 		No 0
SIRT3-010
ENSP00000436085
ENST00000525237
E9PR48 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
 18 aa
1.8 kDa 		No 0
SIRT3-011
ENSP00000433132
ENST00000525776
E9PM52 [Direct mapping]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0070403 [NAD+ binding]
Show all
 23 aa
2.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.