Cell atlas - SIRT3 - The Human Protein Atlas

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SIRT3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SIRT3
Gene description	Sirtuin 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SIRT3 (HGNC Symbol)
Synonyms	SIR2L3
Description	Sirtuin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	215458 - 236931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142082 (version 83.38)
Entrez gene	23410
UniProt	Q9NTG7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NTG7
Antibodypedia	SIRT3 antibodies

PROTEIN BROWSER

SIRT3-001	SIRT3-002	SIRT3-003	SIRT3-004	SIRT3-008	SIRT3-009	SIRT3-010	SIRT3-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIRT3-001 ENSP00000372191 ENST00000382743	Q9NTG7 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006476 [protein deacetylation] GO:0006996 [organelle organization] GO:0007005 [mitochondrion organization] GO:0008270 [zinc ion binding] GO:0009060 [aerobic respiration] GO:0016020 [membrane] GO:0016787 [hydrolase activity] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)] GO:0034983 [peptidyl-lysine deacetylation] GO:0051287 [NAD binding] GO:0070403 [NAD+ binding] GO:0070932 [histone H3 deacetylation] GO:2000757 [negative regulation of peptidyl-lysine acetylation] Show all	399 aa 43.6 kDa	No	0
SIRT3-002 ENSP00000432937 ENST00000524564	E9PN58 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006476 [protein deacetylation] GO:0008270 [zinc ion binding] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0051287 [NAD binding] GO:0070403 [NAD+ binding] Show all	353 aa 39.2 kDa	No	0
SIRT3-003 ENSP00000435464 ENST00000525319	E9PK80 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006476 [protein deacetylation] GO:0008270 [zinc ion binding] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0051287 [NAD binding] GO:0070403 [NAD+ binding] Show all	318 aa 35.1 kDa	No	0
SIRT3-004 ENSP00000433077 ENST00000532956	E9PM75 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070403 [NAD+ binding] Show all	345 aa 37.6 kDa	No	0
SIRT3-008 ENSP00000437216 ENST00000529382	Q9NTG7 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006476 [protein deacetylation] GO:0006996 [organelle organization] GO:0007005 [mitochondrion organization] GO:0008270 [zinc ion binding] GO:0009060 [aerobic respiration] GO:0016787 [hydrolase activity] GO:0016811 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides] GO:0034983 [peptidyl-lysine deacetylation] GO:0051287 [NAD binding] GO:0070403 [NAD+ binding] Show all	257 aa 28.6 kDa	No	0
SIRT3-009 ENSP00000432857 ENST00000528469	E9PNA0 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070403 [NAD+ binding] Show all	93 aa 10.7 kDa	No	0
SIRT3-010 ENSP00000436085 ENST00000525237	E9PR48 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070403 [NAD+ binding] Show all	18 aa 1.8 kDa	No	0
SIRT3-011 ENSP00000433132 ENST00000525776	E9PM52 [Direct mapping] NAD-dependent protein deacetylase sirtuin-3, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0070403 [NAD+ binding] Show all	23 aa 2.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.