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COL6A2

CANCER ATLAS

Gene description

 Collagen, type VI, alpha 2

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007029
HPA030920
HPA038799

GENE INFORMATION

Gene name

 COL6A2

Synonyms

Description

 Collagen, type VI, alpha 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 46098097 - 46132849

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142173 (version 83.38)

Entrez gene

 1292

UniProt

 P12110 (UniProt - Evidence at protein level)

neXtProt

 NX_P12110

Antibodypedia

 COL6A2 antibodies

PROTEIN BROWSER
COL6A2-001
COL6A2-002
COL6A2-003
COL6A2-004
COL6A2-005
COL6A2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COL6A2-001
ENSP00000300527
ENST00000300527
P12110 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0009749 [response to glucose]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0042383 [sarcolemma]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:1903561 [extracellular vesicle]
Show all
 1019 aa
108.6 kDa 		Yes 0
COL6A2-002
ENSP00000380870
ENST00000397763
P12110 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:1903561 [extracellular vesicle]
Show all
 918 aa
97.4 kDa 		Yes 0
COL6A2-003
ENSP00000387115
ENST00000409416
P12110 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:1903561 [extracellular vesicle]
Show all
 828 aa
87.3 kDa 		Yes 0
COL6A2-004
ENSP00000390418
ENST00000436769
C9JH44 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 180 aa
20 kDa 		Yes 0
COL6A2-005
ENSP00000395751
ENST00000413758
H7C0M5 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 250 aa
25.5 kDa 		No 0
COL6A2-201
ENSP00000312529
ENST00000310645
P12110 [Direct mapping]
Collagen alpha-2(VI) chain
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0031012 [extracellular matrix]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0070208 [protein heterotrimerization]
GO:1903561 [extracellular vesicle]
Show all
 828 aa
87.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.