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APP

GENERAL INFORMATION

Gene name

 APP

Gene description

 Amyloid beta (A4) precursor protein

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS and a few other tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001462 , CAB000157
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 APP (HGNC Symbol)

Synonyms

 AD1

Description

 Amyloid beta (A4) precursor protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Chromosome

 21

Cytoband

 q21.3

Chromosome location (bp)

 25880550 - 26171128

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000142192 (version 83.38)

Entrez gene

 351

UniProt

 P05067 (UniProt - Evidence at protein level)

neXtProt

 NX_P05067

Antibodypedia

 APP antibodies

PROTEIN BROWSER
APP-001
APP-002
APP-003
APP-004
APP-005
APP-010
APP-015
APP-016
APP-017
APP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APP-001
ENSP00000350578
ENST00000357903
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 751 aa
84.8 kDa 		Yes 1
APP-002
ENSP00000346129
ENST00000354192
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 639 aa
72.6 kDa 		Yes 1
APP-003
ENSP00000345463
ENST00000348990
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 695 aa
78.7 kDa 		Yes 1
APP-004
ENSP00000284981
ENST00000346798
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0001967 [suckling behavior]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0005911 [cell-cell junction]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0006979 [response to oxidative stress]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008203 [cholesterol metabolic process]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010288 [response to lead ion]
GO:0010468 [regulation of gene expression]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0010952 [positive regulation of peptidase activity]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0016504 [peptidase activator activity]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030134 [ER to Golgi transport vesicle]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0030900 [forebrain development]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0031594 [neuromuscular junction]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035253 [ciliary rootlet]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043005 [neuron projection]
GO:0043195 [terminal bouton]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0043393 [regulation of protein binding]
GO:0044267 [cellular protein metabolic process]
GO:0044304 [main axon]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050885 [neuromuscular process controlling balance]
GO:0051124 [synaptic growth at neuromuscular junction]
GO:0051233 [spindle midzone]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0051563 [smooth endoplasmic reticulum calcium ion homeostasis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070851 [growth factor receptor binding]
GO:0071320 [cellular response to cAMP]
GO:0071874 [cellular response to norepinephrine stimulus]
GO:0097449 [astrocyte projection]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990761 [growth cone lamellipodium]
GO:1990812 [growth cone filopodium]
Show all
 770 aa
86.9 kDa 		Yes 1
APP-005
ENSP00000396923
ENST00000448850
H7C0V9 [Direct mapping]
Amyloid beta A4 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0046914 [transition metal ion binding]
Show all
 485 aa
55 kDa 		No 0
APP-010
ENSP00000406539
ENST00000415997
H7C2L2 [Direct mapping]
Amyloid beta A4 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007399 [nervous system development]
Show all
 181 aa
20.3 kDa 		No 0
APP-015
ENSP00000398879
ENST00000439274
E9PG40 [Direct mapping]
Amyloid beta A4 protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005794 [Golgi apparatus]
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046914 [transition metal ion binding]
Show all
 714 aa
80.8 kDa 		Yes 1
APP-016
ENSP00000387483
ENST00000440126
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 746 aa
84.5 kDa 		No 1
APP-017
ENSP00000351796
ENST00000358918
P05067 [Direct mapping]
Amyloid beta A4 protein N-APP Soluble APP-alpha Soluble APP-beta C99 Beta-amyloid protein 42 Beta-amyloid protein 40 C83 P3(42) P3(40) C80 Gamma-secretase C-terminal fragment 59 Gamma-secretase C-terminal fragment 57 Gamma-secretase C-terminal fragment 50 C31
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001878 [response to yeast]
GO:0002576 [platelet degranulation]
GO:0003677 [DNA binding]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005905 [coated pit]
GO:0006378 [mRNA polyadenylation]
GO:0006417 [regulation of translation]
GO:0006468 [protein phosphorylation]
GO:0006878 [cellular copper ion homeostasis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006897 [endocytosis]
GO:0007155 [cell adhesion]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007219 [Notch signaling pathway]
GO:0007409 [axonogenesis]
GO:0007596 [blood coagulation]
GO:0007617 [mating behavior]
GO:0007626 [locomotory behavior]
GO:0008088 [axon cargo transport]
GO:0008201 [heparin binding]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0016199 [axon midline choice point recognition]
GO:0016322 [neuron remodeling]
GO:0016358 [dendrite development]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0019899 [enzyme binding]
GO:0030168 [platelet activation]
GO:0030198 [extracellular matrix organization]
GO:0030424 [axon]
GO:0031093 [platelet alpha granule lumen]
GO:0031175 [neuron projection development]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0033130 [acetylcholine receptor binding]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0040014 [regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043235 [receptor complex]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045202 [synapse]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046914 [transition metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048669 [collateral sprouting in absence of injury]
GO:0050803 [regulation of synapse structure or activity]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051402 [neuron apoptotic process]
GO:0051425 [PTB domain binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
Show all
 752 aa
85 kDa 		Yes 1
APP-201
ENSP00000352760
ENST00000359726
A0A0A0MRG2 [Direct mapping]
Amyloid beta A4 protein
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007399 [nervous system development]
GO:0008201 [heparin binding]
GO:0016021 [integral component of membrane]
GO:0046914 [transition metal ion binding]
Show all
 660 aa
75.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.