Cell atlas - SIGLEC10 - The Human Protein Atlas

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SIGLEC10

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Cytosol
	Plasma membrane

Human cell
	Actin Filaments
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SIGLEC10
Gene description	Sialic acid binding Ig-like lectin 10
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane & actin filaments.
RNA cell category	Cell line enhanced (Daudi, U-698, HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Plasma membrane (supported), Actin filaments (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB025807 , HPA027093
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Daudi, U-698, HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane & actin filaments.

Main location

Cytosol (supported)

Additional location

Plasma membrane (supported), Actin filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB025807	A-431	Plasma membrane
			Actin filaments
			Cytosol
	CAB025807	U-2 OS	Plasma membrane
			Actin filaments
			Cytosol
	CAB025807	U-251 MG	Plasma membrane
	CAB025807	U-251 MG	Cytosol
	HPA027093	A-431	Cytosol
	HPA027093	U-2 OS	Cytosol
	HPA027093	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SIGLEC10 (HGNC Symbol)
Synonyms	MGC126774, PRO940, SIGLEC-10, SLG2
Description	Sialic acid binding Ig-like lectin 10 (HGNC Symbol)
Entrez gene summary	SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51410021 - 51417803
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142512 (version 83.38)
Entrez gene	89790
UniProt	Q96LC7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96LC7
Antibodypedia	SIGLEC10 antibodies

PROTEIN BROWSER

SIGLEC10-001	SIGLEC10-002	SIGLEC10-003	SIGLEC10-005	SIGLEC10-006	SIGLEC10-007	SIGLEC10-008	SIGLEC10-010	SIGLEC10-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIGLEC10-001 ENSP00000345243 ENST00000339313	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	697 aa 76.6 kDa	Yes	1
SIGLEC10-002 ENSP00000342389 ENST00000353836	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	602 aa 66.6 kDa	Yes	1
SIGLEC10-003 ENSP00000389132 ENST00000439889	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	639 aa 70.3 kDa	Yes	1
SIGLEC10-005 ENSP00000414324 ENST00000436984	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	554 aa 61.4 kDa	Yes	1
SIGLEC10-006 ENSP00000408387 ENST00000441969	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	544 aa 60.3 kDa	Yes	1
SIGLEC10-007 ENSP00000431444 ENST00000525998	E9PL79 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	512 aa 56.8 kDa	Yes	1
SIGLEC10-008 ENSP00000435281 ENST00000529627	E9PKV9 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	155 aa 17 kDa	Yes	0
SIGLEC10-010 ENSP00000433838 ENST00000530476	E9PJA1 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	186 aa 21.1 kDa	No	0
SIGLEC10-012 ENSP00000395475 ENST00000442846	Q96LC7 [Direct mapping] Sialic acid-binding Ig-like lectin 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	454 aa 50.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.