Tissue expression of CNKSR1 - Summary - The Human Protein Atlas

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CNKSR1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CNKSR1
Gene description	Connector enhancer of kinase suppressor of Ras 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA030847
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (skeletal muscle)

GENE INFORMATION
Gene name	CNKSR1 (HGNC Symbol)
Synonyms	CNK, CNK1, KSR
Description	Connector enhancer of kinase suppressor of Ras 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	26177403 - 26189886
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142675 (version 83.38)
Entrez gene	10256
UniProt	Q969H4 (UniProt - Evidence at protein level)
neXtProt	NX_Q969H4
Antibodypedia	CNKSR1 antibodies

PROTEIN BROWSER

CNKSR1-001	CNKSR1-003	CNKSR1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNKSR1-001 ENSP00000354609 ENST00000361530	Q969H4 [Direct mapping] Connector enhancer of kinase suppressor of ras 1 Q53GM7 [Target identity:100%; Query identity:100%] Connector enhancer of kinase suppressor of Ras 1 variant; Connector enhancer of kinase suppressor of Ras 1, isoform CRA_b Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005938 [cell cortex] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007266 [Rho protein signal transduction] GO:0030674 [protein binding, bridging] Show all	713 aa 78.8 kDa	No	0
CNKSR1-003 ENSP00000431817 ENST00000531191	G3V160 [Direct mapping] Connector enhancer of kinase suppressor of Ras 1, isoform CRA_a; Connector enhancer of kinase suppressor of ras 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	455 aa 50.2 kDa	No	0
CNKSR1-007 ENSP00000363371 ENST00000374253	Q969H4 [Direct mapping] Connector enhancer of kinase suppressor of ras 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005938 [cell cortex] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0007266 [Rho protein signal transduction] GO:0030674 [protein binding, bridging] Show all	720 aa 79.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.