Tissue expression of PROK1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PROK1
Gene description	Prokineticin 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (ovary, testis, placenta)
GTEx:	Group enriched (ovary, testis)
FANTOM5:	Group enriched (ovary, testis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (ovary, testis, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (ovary, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (ovary, testis)

GENE INFORMATION
Gene name	PROK1 (HGNC Symbol)
Synonyms	EGVEGF, PK1, PRK1
Description	Prokineticin 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	110451200 - 110457354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143125 (version 83.38)
Entrez gene	84432
UniProt	P58294 (UniProt - Evidence at protein level)
neXtProt	NX_P58294
Antibodypedia	PROK1 antibodies

PROTEIN BROWSER

PROK1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROK1-001 ENSP00000271331 ENST00000271331	P58294 [Direct mapping] Prokineticin-1 A0A024R0B1 [Target identity:100%; Query identity:100%] Prokineticin 1, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0000187 [activation of MAPK activity] GO:0001525 [angiogenesis] GO:0001664 [G-protein coupled receptor binding] GO:0005576 [extracellular region] GO:0007623 [circadian rhythm] GO:0008083 [growth factor activity] GO:0008284 [positive regulation of cell proliferation] GO:0045765 [regulation of angiogenesis] GO:0051781 [positive regulation of cell division] Show all	105 aa 11.7 kDa	Yes	0