Expression of CELSR2 in cancer - Summary

CANCER ATLAS

Gene description

Cadherin, EGF LAG seven-pass G-type receptor 2

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013952

GENE INFORMATION
Gene name	CELSR2 (HGNC Symbol)
Synonyms	ADGRC2, CDHF10, EGFL2, Flamingo1, KIAA0279, MEGF3
Description	Cadherin, EGF LAG seven-pass G-type receptor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p13.3
Chromosome location (bp)	109250019 - 109275750
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143126 (version 83.38)
Entrez gene	1952
UniProt	Q9HCU4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCU4
Antibodypedia	CELSR2 antibodies

PROTEIN BROWSER

CELSR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELSR2-001 ENSP00000271332 ENST00000271332	Q9HCU4 [Direct mapping] Cadherin EGF LAG seven-pass G-type receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003341 [cilium movement] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006355 [regulation of transcription, DNA-templated] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007283 [spermatogenesis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0021591 [ventricular system development] GO:0021999 [neural plate anterior/posterior regionalization] GO:0022407 [regulation of cell-cell adhesion] GO:0032880 [regulation of protein localization] GO:0033326 [cerebrospinal fluid secretion] GO:0042384 [cilium assembly] GO:0048813 [dendrite morphogenesis] Show all	2923 aa 317.4 kDa	Yes	7