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CELSR2

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GENERAL INFORMATION

Gene name

 CELSR2

Gene description

 Cadherin, EGF LAG seven-pass G-type receptor 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Cell line enhanced (AF22, MCF7, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA013952
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, MCF7, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA013952 A-431 Cytosol
HPA013952 U-251 MG Cytosol

GENE INFORMATION

Gene name

 CELSR2 (HGNC Symbol)

Synonyms

 ADGRC2, CDHF10, EGFL2, Flamingo1, KIAA0279, MEGF3

Description

 Cadherin, EGF LAG seven-pass G-type receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p13.3

Chromosome location (bp)

 109250019 - 109275750

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143126 (version 83.38)

Entrez gene

 1952

UniProt

 Q9HCU4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCU4

Antibodypedia

 CELSR2 antibodies

PROTEIN BROWSER
CELSR2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CELSR2-001
ENSP00000271332
ENST00000271332
Q9HCU4 [Direct mapping]
Cadherin EGF LAG seven-pass G-type receptor 2
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G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001764 [neuron migration]
GO:0003341 [cilium movement]
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007283 [spermatogenesis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0021591 [ventricular system development]
GO:0021999 [neural plate anterior/posterior regionalization]
GO:0022407 [regulation of cell-cell adhesion]
GO:0032880 [regulation of protein localization]
GO:0033326 [cerebrospinal fluid secretion]
GO:0042384 [cilium assembly]
GO:0048813 [dendrite morphogenesis]
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 2923 aa
317.4 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.