Expression of TBX19 in cancer - Summary

CANCER ATLAS

Gene description

T-box 19

Protein class

Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005800

GENE INFORMATION
Gene name	TBX19 (HGNC Symbol)
Synonyms	dj747L4.1, TPIT
Description	T-box 19 (HGNC Symbol)
Entrez gene summary	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	168281040 - 168314426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143178 (version 83.38)
Entrez gene	9095
UniProt	O60806 (UniProt - Evidence at protein level)
neXtProt	NX_O60806
Antibodypedia	TBX19 antibodies

PROTEIN BROWSER

TBX19-001	TBX19-003	TBX19-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX19-001 ENSP00000356795 ENST00000367821	O60806 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0021983 [pituitary gland development] GO:0042127 [regulation of cell proliferation] GO:0045165 [cell fate commitment] GO:0045595 [regulation of cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	448 aa 48.2 kDa	No	0
TBX19-003 ENSP00000390731 ENST00000441464	H0Y4B1 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	281 aa 29.8 kDa	No	0
TBX19-004 ENSP00000397540 ENST00000431969	H0Y5A7 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	318 aa 33.8 kDa	No	0