Cell atlas - TBX19 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TBX19

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	TBX19
Gene description	T-box 19
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (approved)
Mouse	Localized to the Intermediate filaments in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA005800
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005800	A-431	Nuclear speckles
	HPA005800	U-2 OS	Nuclear speckles
	HPA005800	U-251 MG	Nuclear speckles

MOUSE CELLS

Main location

Intermediate filaments

Mouse gene

ENSMUSG00000026572 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA005800	NIH 3T3	Intermediate filaments

GENE INFORMATION
Gene name	TBX19 (HGNC Symbol)
Synonyms	dj747L4.1, TPIT
Description	T-box 19 (HGNC Symbol)
Entrez gene summary	This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q24.2
Chromosome location (bp)	168281040 - 168314426
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143178 (version 83.38)
Entrez gene	9095
UniProt	O60806 (UniProt - Evidence at protein level)
neXtProt	NX_O60806
Antibodypedia	TBX19 antibodies

PROTEIN BROWSER

TBX19-001	TBX19-003	TBX19-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBX19-001 ENSP00000356795 ENST00000367821	O60806 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Disease related genes Show all	GO:0001158 [enhancer sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0021983 [pituitary gland development] GO:0042127 [regulation of cell proliferation] GO:0045165 [cell fate commitment] GO:0045595 [regulation of cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	448 aa 48.2 kDa	No	0
TBX19-003 ENSP00000390731 ENST00000441464	H0Y4B1 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	281 aa 29.8 kDa	No	0
TBX19-004 ENSP00000397540 ENST00000431969	H0Y5A7 [Direct mapping] T-box transcription factor TBX19 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	318 aa 33.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.