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Cancer tissues showed weak to moderate nuclear staining. Few cases of melanoma displayed strong immunoreactivity. Several cases of colorectal and few endometrial cancers displayed additional membranous staining.
Malignant cells showed weak to moderate nuclear immunoreactivity. A few cases of urothelial, testicular and cervical cancers were strongly stained. Malignant gliomas and most renal cancers were negative.
GENE INFORMATION
Gene name
POU2F1 (HGNC Symbol)
Synonyms
OCT1, OTF1
Description
POU class 2 homeobox 1 (HGNC Symbol)
Entrez gene summary
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
P14859 [Direct mapping] POU domain, class 2, transcription factor 1
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000976 [transcription regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0010467 [gene expression] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0097421 [liver regeneration]
P14859 [Direct mapping] POU domain, class 2, transcription factor 1
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0010467 [gene expression] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated]
P14859 [Direct mapping] POU domain, class 2, transcription factor 1
Show all
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006383 [transcription from RNA polymerase III promoter] GO:0010467 [gene expression] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated]
