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POU2F1

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GENERAL INFORMATION

Gene name

 POU2F1

Gene description

 POU class 2 homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm & vesicles. In addition localized to the endoplasmic reticulum.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Vesicles (supported)

Additional location

 In addition localized to the Endoplasmic reticulum (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA058559 , HPA064323
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm & vesicles. In addition localized to the endoplasmic reticulum.

Main location

 Nucleoplasm (supported), Vesicles (supported)

Additional location

 Endoplasmic reticulum (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA058559 A-431 Nucleoplasm
Vesicles Intensity
HPA058559 CACO-2 Nucleoplasm
Vesicles
HPA058559 U-2 OS Nucleoplasm
Endoplasmic reticulum
HPA064323 A-431 Nucleoplasm
Vesicles
HPA064323 SH-SY5Y Nucleoplasm
HPA064323 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 POU2F1 (HGNC Symbol)

Synonyms

 OCT1, OTF1

Description

 POU class 2 homeobox 1 (HGNC Symbol)

Entrez gene summary

 The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

Chromosome

 1

Cytoband

 q24.2

Chromosome location (bp)

 167220829 - 167427345

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143190 (version 83.38)

Entrez gene

 5451

UniProt

 P14859 (UniProt - Evidence at protein level)

neXtProt

 NX_P14859

Antibodypedia

 POU2F1 antibodies

PROTEIN BROWSER
POU2F1-002
POU2F1-003
POU2F1-005
POU2F1-010
POU2F1-014
POU2F1-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU2F1-002
ENSP00000356840
ENST00000367866
P14859 [Direct mapping]
POU domain, class 2, transcription factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000976 [transcription regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0010467 [gene expression]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0097421 [liver regeneration]
Show all
 766 aa
78.5 kDa 		No 0
POU2F1-003
ENSP00000356836
ENST00000367862
P14859 [Direct mapping]
POU domain, class 2, transcription factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0010467 [gene expression]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 755 aa
77.9 kDa 		No 0
POU2F1-005
ENSP00000415993
ENST00000443275
A0A0C4DG88 [Direct mapping]
POU domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 561 aa
58.7 kDa 		No 0
POU2F1-010
ENSP00000401217
ENST00000429375
P14859 [Direct mapping]
POU domain, class 2, transcription factor 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0010467 [gene expression]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 703 aa
72.1 kDa 		No 0
POU2F1-014
ENSP00000414660
ENST00000420254
A0A0A0MT46 [Direct mapping]
POU domain protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 594 aa
61.6 kDa 		No 0
POU2F1-017
ENSP00000441285
ENST00000541643
P14859 [Direct mapping]
POU domain, class 2, transcription factor 1
A0A024R8Y2 [Target identity:100%; Query identity:100%]
POU domain protein
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006383 [transcription from RNA polymerase III promoter]
GO:0010467 [gene expression]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
Show all
 743 aa
76.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.