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TUFT1

GENERAL INFORMATION

Gene name

 TUFT1

Gene description

 Tuftelin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA028112 , HPA054301
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TUFT1

Synonyms

Description

 Tuftelin 1 (HGNC Symbol)

Entrez gene summary

 Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth factor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 151540305 - 151583583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143367 (version 83.38)

Entrez gene

 7286

UniProt

 Q9NNX1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NNX1

Antibodypedia

 TUFT1 antibodies

PROTEIN BROWSER
TUFT1-006
TUFT1-008
TUFT1-010
TUFT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUFT1-006
ENSP00000357842
ENST00000368849
Q9NNX1 [Direct mapping]
Tuftelin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0030282 [bone mineralization]
GO:0030345 [structural constituent of tooth enamel]
GO:0042476 [odontogenesis]
Show all
 390 aa
44.3 kDa 		No 0
TUFT1-008
ENSP00000357841
ENST00000368848
Q9NNX1 [Direct mapping]
Tuftelin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0030282 [bone mineralization]
GO:0030345 [structural constituent of tooth enamel]
GO:0042476 [odontogenesis]
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 365 aa
41.5 kDa 		No 0
TUFT1-010
ENSP00000376476
ENST00000392712
A6PVU8 [Direct mapping]
Tuftelin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 335 aa
38 kDa 		No 0
TUFT1-201
ENSP00000343781
ENST00000353024
Q6UWW7 [Direct mapping]
TUFT1; Tuftelin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 199 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.