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ARNT

GENERAL INFORMATION

Gene name

 ARNT

Gene description

 Aryl hydrocarbon receptor nuclear translocator

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001759 , CAB004318
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARNT (HGNC Symbol)

Synonyms

 bHLHe2, HIF-1beta

Description

 Aryl hydrocarbon receptor nuclear translocator (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 150809705 - 150876768

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143437 (version 83.38)

Entrez gene

 405

UniProt

 P27540 (UniProt - Evidence at protein level)

neXtProt

 NX_P27540

Antibodypedia

 ARNT antibodies

PROTEIN BROWSER
ARNT-001
ARNT-006
ARNT-009
ARNT-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARNT-001
ENSP00000351407
ENST00000358595
P27540 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001666 [response to hypoxia]
GO:0001892 [embryonic placenta development]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003713 [transcription coactivator activity]
GO:0004874 [aryl hydrocarbon receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0030154 [cell differentiation]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0033235 [positive regulation of protein sumoylation]
GO:0035326 [enhancer binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046886 [positive regulation of hormone biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 789 aa
86.6 kDa 		No 0
ARNT-006
ENSP00000423851
ENST00000515192
P27540 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035326 [enhancer binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046886 [positive regulation of hormone biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 775 aa
85.3 kDa 		No 0
ARNT-009
ENSP00000427571
ENST00000505755
P27540 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035326 [enhancer binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046886 [positive regulation of hormone biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 774 aa
84.9 kDa 		No 0
ARNT-010
ENSP00000346372
ENST00000354396
P27540 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0017162 [aryl hydrocarbon receptor binding]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0035326 [enhancer binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043565 [sequence-specific DNA binding]
GO:0043619 [regulation of transcription from RNA polymerase II promoter in response to oxidative stress]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045821 [positive regulation of glycolytic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046886 [positive regulation of hormone biosynthetic process]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0071456 [cellular response to hypoxia]
GO:0090575 [RNA polymerase II transcription factor complex]
Show all
 787 aa
86.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.