Cell atlas - POGZ - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

POGZ

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	POGZ
Gene description	Pogo transposable element with ZNF domain
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	12
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA006800 , HPA008781
	SHOW MORE

ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA006800	A-431	Nucleoplasm
HPA006800	A-431	Cytosol
HPA006800	U-2 OS	Nucleoplasm
HPA006800	U-251 MG	Nucleoplasm
HPA008781	A-431	Nucleoplasm
HPA008781	A-431	Cytosol
HPA008781	U-2 OS	Nucleus
HPA008781	U-251 MG	Nucleus

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA006800

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

55%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA006800	siRNA 1	U-2 OS
		HPA006800	scrambled	U-2 OS

GENE INFORMATION
Gene name	POGZ (HGNC Symbol)
Synonyms	KIAA0461, ZNF280E, ZNF635m
Description	Pogo transposable element with ZNF domain (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	151402724 - 151459465
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143442 (version 83.38)
Entrez gene	23126
UniProt	Q7Z3K3 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z3K3
Antibodypedia	POGZ antibodies

PROTEIN BROWSER

POGZ-001	POGZ-002	POGZ-003	POGZ-009	POGZ-010	POGZ-011	POGZ-016	POGZ-017	POGZ-018	POGZ-019	POGZ-020	POGZ-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POGZ-001 ENSP00000271715 ENST00000271715	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1410 aa 155.3 kDa	No	0
POGZ-002 ENSP00000376484 ENST00000392723	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1357 aa 150.1 kDa	No	0
POGZ-003 ENSP00000357856 ENST00000368863	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1315 aa 145.3 kDa	No	0
POGZ-009 ENSP00000390156 ENST00000439756	A0A0G2JHK5 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.9 kDa	No	0
POGZ-010 ENSP00000395332 ENST00000450842	A6PW30 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.3 kDa	No	0
POGZ-011 ENSP00000418408 ENST00000491586	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1366 aa 151.2 kDa	No	0
POGZ-016 ENSP00000386836 ENST00000409503	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1401 aa 154.5 kDa	No	0
POGZ-017 ENSP00000431259 ENST00000531094	Q7Z3K3 [Direct mapping] Pogo transposable element with ZNF domain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0007064 [mitotic sister chromatid cohesion] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0051382 [kinetochore assembly] Show all	1348 aa 149.3 kDa	No	0
POGZ-018 ENSP00000433934 ENST00000533461	E9PIR8 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 15.9 kDa	No	0
POGZ-019 ENSP00000433637 ENST00000533351	E9PJY9 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 14.7 kDa	No	0
POGZ-020 ENSP00000432295 ENST00000529669	H0YCT3 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	316 aa 35.4 kDa	No	0
POGZ-021 ENSP00000472860 ENST00000594456	M0R2X2 [Direct mapping] Pogo transposable element with ZNF domain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 11.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.