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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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RAB13
  • TISSUE

  • premium

    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

RAB13, member RAS oncogene family

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY

HPA003996

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Breast cancer, melanomas and selected cases of prostate cancer showed moderate cytoplasmic positivity. Remaining cancers were weakly stained or negative.

GENE INFORMATION

Gene name

RAB13

Synonyms

Description

RAB13, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

153981617 - 153986358

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143545 (version 83.38)

Entrez gene

5872

UniProt

P51153 (UniProt - Evidence at protein level)

neXtProt

NX_P51153

Antibodypedia

RAB13 antibodies

PROTEIN BROWSER

RAB13-001
RAB13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAB13-001
ENSP00000357564
ENST00000368575
P51153 [Direct mapping]
Ras-related protein Rab-13
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010737 [protein kinase A signaling]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016197 [endosomal transport]
GO:0016328 [lateral plasma membrane]
GO:0030027 [lamellipodium]
GO:0030139 [endocytic vesicle]
GO:0030658 [transport vesicle membrane]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0031175 [neuron projection development]
GO:0031410 [cytoplasmic vesicle]
GO:0032456 [endocytic recycling]
GO:0032482 [Rab protein signal transduction]
GO:0032593 [insulin-responsive compartment]
GO:0032869 [cellular response to insulin stimulus]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0035767 [endothelial cell chemotaxis]
GO:0043005 [neuron projection]
GO:0044795 [trans-Golgi network to recycling endosome transport]
GO:0055037 [recycling endosome]
GO:0055038 [recycling endosome membrane]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
GO:0072659 [protein localization to plasma membrane]
GO:0090002 [establishment of protein localization to plasma membrane]
GO:0097368 [establishment of Sertoli cell barrier]
GO:1902463 [protein localization to cell leading edge]
Show all
203 aa
22.8 kDa
No 0
RAB13-201
ENSP00000480103
ENST00000614713
A0A087WWB9 [Direct mapping]
Ras-related protein Rab-13
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030866 [cortical actin cytoskeleton organization]
GO:0032482 [Rab protein signal transduction]
Show all
122 aa
13.6 kDa
No 0

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The Human Protein Atlas project is funded
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