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The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq, Jul 2008]
P05109 [Direct mapping] Protein S100-A8 Protein S100-A8, N-terminally processed
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Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001816 [cytokine production] GO:0002523 [leukocyte migration involved in inflammatory response] GO:0002526 [acute inflammatory response] GO:0002544 [chronic inflammatory response] GO:0002793 [positive regulation of peptide secretion] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006914 [autophagy] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006954 [inflammatory response] GO:0008017 [microtubule binding] GO:0008270 [zinc ion binding] GO:0010043 [response to zinc ion] GO:0014002 [astrocyte development] GO:0018119 [peptidyl-cysteine S-nitrosylation] GO:0030307 [positive regulation of cell growth] GO:0030593 [neutrophil chemotaxis] GO:0032119 [sequestering of zinc ion] GO:0032496 [response to lipopolysaccharide] GO:0032602 [chemokine production] GO:0035662 [Toll-like receptor 4 binding] GO:0042060 [wound healing] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] GO:0045471 [response to ethanol] GO:0050544 [arachidonic acid binding] GO:0050729 [positive regulation of inflammatory response] GO:0050786 [RAGE receptor binding] GO:0050832 [defense response to fungus] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051493 [regulation of cytoskeleton organization] GO:0070062 [extracellular exosome] GO:0070488 [neutrophil aggregation] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]