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SNAPIN

GENERAL INFORMATION

Gene name

 SNAPIN

Gene description

 SNAP-associated protein

Protein class

 Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA046974
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin051015202530RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

 SNAPIN (HGNC Symbol)

Synonyms

 BLOC1S7, BORCS3, SNAPAP

Description

 SNAP-associated protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Chromosome

 1

Cytoband

 q21.3

Chromosome location (bp)

 153658654 - 153661830

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143553 (version 83.38)

Entrez gene

 23557

UniProt

 O95295 (UniProt - Evidence at protein level)

neXtProt

 NX_O95295

Antibodypedia

 SNAPIN antibodies

PROTEIN BROWSER
SNAPIN-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNAPIN-001
ENSP00000357674
ENST00000368685
O95295 [Direct mapping]
SNARE-associated protein Snapin
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Transporters
   Transporter channels and pores
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000149 [SNARE binding]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008089 [anterograde axon cargo transport]
GO:0008333 [endosome to lysosome transport]
GO:0010977 [negative regulation of neuron projection development]
GO:0016032 [viral process]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016188 [synaptic vesicle maturation]
GO:0030054 [cell junction]
GO:0030133 [transport vesicle]
GO:0030141 [secretory granule]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030672 [synaptic vesicle membrane]
GO:0031083 [BLOC-1 complex]
GO:0031175 [neuron projection development]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0032438 [melanosome organization]
GO:0043393 [regulation of protein binding]
GO:0045202 [synapse]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048489 [synaptic vesicle transport]
GO:0048490 [anterograde synaptic vesicle transport]
GO:0072553 [terminal button organization]
GO:0097352 [autophagosome maturation]
GO:1902824 [positive regulation of late endosome to lysosome transport]
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 136 aa
14.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.