Expression of HCN3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hyperpolarization activated cyclic nucleotide gated potassium channel 3

Protein class

Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026584

GENE INFORMATION
Gene name	HCN3 (HGNC Symbol)
Synonyms	KIAA1535
Description	Hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155277583 - 155289848
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000143630 (version 83.38)
Entrez gene	57657
UniProt	Q9P1Z3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9P1Z3
Antibodypedia	HCN3 antibodies

PROTEIN BROWSER

HCN3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCN3-001 ENSP00000357342 ENST00000368358	Q9P1Z3 [Direct mapping] Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 Show all	Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins Show all	GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007268 [synaptic transmission] GO:0016020 [membrane] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030552 [cAMP binding] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0043025 [neuronal cell body] GO:0044316 [cone cell pedicle] GO:0045202 [synapse] GO:0055085 [transmembrane transport] GO:0071805 [potassium ion transmembrane transport] GO:0072718 [response to cisplatin] GO:1903351 [cellular response to dopamine] Show all	774 aa 86 kDa	No	5