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HCN3

GENERAL INFORMATION

Gene name

 HCN3

Gene description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 3

Protein class

 Plasma proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum, pituitary gland)

Protein evidence

 Evidence at transcript level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA026584
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, pituitary gland)

GENE INFORMATION

Gene name

 HCN3 (HGNC Symbol)

Synonyms

 KIAA1535

Description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 155277583 - 155289848

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000143630 (version 83.38)

Entrez gene

 57657

UniProt

 Q9P1Z3 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9P1Z3

Antibodypedia

 HCN3 antibodies

PROTEIN BROWSER
HCN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCN3-001
ENSP00000357342
ENST00000368358
Q9P1Z3 [Direct mapping]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
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Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Plasma proteins
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GO:0005216 [ion channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030552 [cAMP binding]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0043025 [neuronal cell body]
GO:0044316 [cone cell pedicle]
GO:0045202 [synapse]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:0072718 [response to cisplatin]
GO:1903351 [cellular response to dopamine]
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 774 aa
86 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.