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THNSL2

CANCER ATLAS

Gene description

 Threonine synthase-like 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA035395

GENE INFORMATION

Gene name

 THNSL2 (HGNC Symbol)

Synonyms

 FLJ10916, SOFAT, TSH2

Description

 Threonine synthase-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 88170295 - 88186636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144115 (version 83.38)

Entrez gene

 55258

UniProt

 Q86YJ6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86YJ6

Antibodypedia

 THNSL2 antibodies

PROTEIN BROWSER
THNSL2-001
THNSL2-002
THNSL2-004
THNSL2-005
THNSL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
THNSL2-001
ENSP00000327323
ENST00000324166
Q86YJ6 [Direct mapping]
Threonine synthase-like 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005125 [cytokine activity]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0009071 [serine family amino acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0046360 [2-oxobutyrate biosynthetic process]
GO:0070905 [serine binding]
Show all
 484 aa
54.1 kDa 		No 0
THNSL2-002
ENSP00000339563
ENST00000343544
Q86YJ6 [Direct mapping]
Threonine synthase-like 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005125 [cytokine activity]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0009071 [serine family amino acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0046360 [2-oxobutyrate biosynthetic process]
GO:0070905 [serine binding]
Show all
 405 aa
45 kDa 		No 0
THNSL2-004
ENSP00000407553
ENST00000449349
C9JU10 [Direct mapping]
Threonine synthase-like 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 258 aa
28.7 kDa 		No 0
THNSL2-005
ENSP00000391300
ENST00000419759
C9J3J1 [Direct mapping]
Threonine synthase-like 2
Show all
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 126 aa
14.4 kDa 		No 0
THNSL2-201
ENSP00000366464
ENST00000377254
A8K0C1 [Direct mapping]
Threonine synthase-like 2; cDNA FLJ76990; cDNA, FLJ79480
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 226 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.