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THNSL2

GENERAL INFORMATION

Gene name

 THNSL2

Gene description

 Threonine synthase-like 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035395
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 THNSL2 (HGNC Symbol)

Synonyms

 FLJ10916, SOFAT, TSH2

Description

 Threonine synthase-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 88170295 - 88186636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144115 (version 83.38)

Entrez gene

 55258

UniProt

 Q86YJ6 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86YJ6

Antibodypedia

 THNSL2 antibodies

PROTEIN BROWSER
THNSL2-001
THNSL2-002
THNSL2-004
THNSL2-005
THNSL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
THNSL2-001
ENSP00000327323
ENST00000324166
Q86YJ6 [Direct mapping]
Threonine synthase-like 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005125 [cytokine activity]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0009071 [serine family amino acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0046360 [2-oxobutyrate biosynthetic process]
GO:0070905 [serine binding]
Show all
 484 aa
54.1 kDa 		No 0
THNSL2-002
ENSP00000339563
ENST00000343544
Q86YJ6 [Direct mapping]
Threonine synthase-like 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005125 [cytokine activity]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0008150 [biological_process]
GO:0009071 [serine family amino acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0030170 [pyridoxal phosphate binding]
GO:0046360 [2-oxobutyrate biosynthetic process]
GO:0070905 [serine binding]
Show all
 405 aa
45 kDa 		No 0
THNSL2-004
ENSP00000407553
ENST00000449349
C9JU10 [Direct mapping]
Threonine synthase-like 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 258 aa
28.7 kDa 		No 0
THNSL2-005
ENSP00000391300
ENST00000419759
C9J3J1 [Direct mapping]
Threonine synthase-like 2
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Predicted intracellular proteins
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 126 aa
14.4 kDa 		No 0
THNSL2-201
ENSP00000366464
ENST00000377254
A8K0C1 [Direct mapping]
Threonine synthase-like 2; cDNA FLJ76990; cDNA, FLJ79480
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0030170 [pyridoxal phosphate binding]
Show all
 226 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.