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Several cases of testicular and prostate cancers along with a few cases of gliomas and colorectal cancers showed moderate nuclear staining. Remaining cancer tissues were weakly stained or negative.
Most cancer tissues showed weak to moderate nuclear immunoreactivity. A few colorectal and gastric cancers were strongly stained. Hepatocellular carcinomas as well as most gliomas, endometrial, lung and renal cancers were negative.
Q8N5P1 [Direct mapping] Zinc finger CCCH domain-containing protein 8
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Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0008023 [transcription elongation factor complex] GO:0015030 [Cajal body] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0035327 [transcriptionally active chromatin] GO:0035363 [histone locus body] GO:0042795 [snRNA transcription from RNA polymerase II promoter] GO:0042796 [snRNA transcription from RNA polymerase III promoter] GO:0043029 [T cell homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0070245 [positive regulation of thymocyte apoptotic process]