Cell atlas - ZC3H8 - The Human Protein Atlas

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ZC3H8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ZC3H8
Gene description	Zinc finger CCCH-type containing 8
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA034803
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

Nucleoplasm (supported)

Additional location

Nuclear bodies (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034803	U-2 OS	Nucleoplasm
	HPA034803	U-251 MG	Nucleoplasm
	HPA034803	U-251 MG	Nuclear bodies

GENE INFORMATION
Gene name	ZC3H8 (HGNC Symbol)
Synonyms	Fliz1, ZC3HDC8
Description	Zinc finger CCCH-type containing 8 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	112211525 - 112255136
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144161 (version 83.38)
Entrez gene	84524
UniProt	Q8N5P1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5P1
Antibodypedia	ZC3H8 antibodies

PROTEIN BROWSER

ZC3H8-001	ZC3H8-201	ZC3H8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZC3H8-001 ENSP00000386488 ENST00000409573	Q8N5P1 [Direct mapping] Zinc finger CCCH domain-containing protein 8 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0008023 [transcription elongation factor complex] GO:0015030 [Cajal body] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0035327 [transcriptionally active chromatin] GO:0035363 [histone locus body] GO:0042795 [snRNA transcription from RNA polymerase II promoter] GO:0042796 [snRNA transcription from RNA polymerase III promoter] GO:0043029 [T cell homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0070245 [positive regulation of thymocyte apoptotic process] Show all	291 aa 33.6 kDa	No	0
ZC3H8-201 ENSP00000272570 ENST00000272570	Q8N5P1 [Direct mapping] Zinc finger CCCH domain-containing protein 8 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006915 [apoptotic process] GO:0008023 [transcription elongation factor complex] GO:0015030 [Cajal body] GO:0033085 [negative regulation of T cell differentiation in thymus] GO:0035327 [transcriptionally active chromatin] GO:0035363 [histone locus body] GO:0042795 [snRNA transcription from RNA polymerase II promoter] GO:0042796 [snRNA transcription from RNA polymerase III promoter] GO:0043029 [T cell homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046677 [response to antibiotic] GO:0046872 [metal ion binding] GO:0070245 [positive regulation of thymocyte apoptotic process] Show all	291 aa 33.6 kDa	No	0
ZC3H8-202 ENSP00000483976 ENST00000615791	A0A0C4DGZ1 [Direct mapping] Zinc finger CCCH domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	297 aa 34.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.