Tissue expression of LIPT1 - Summary - The Human Protein Atlas

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LIPT1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LIPT1
Gene description	Lipoyltransferase 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Tissue enhanced (testis)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA034802
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LIPT1 (HGNC Symbol)
Synonyms	MGC12290, MGC13378
Description	Lipoyltransferase 1 (HGNC Symbol)
Entrez gene summary	The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	99154955 - 99163157
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144182 (version 83.38)
Entrez gene	51601
UniProt	Q9Y234 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y234
Antibodypedia	LIPT1 antibodies

PROTEIN BROWSER

LIPT1-001	LIPT1-002	LIPT1-003	LIPT1-005	LIPT1-006	LIPT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIPT1-001 ENSP00000377115 ENST00000393473	Q9Y234 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006464 [cellular protein modification process] GO:0006629 [lipid metabolic process] GO:0009249 [protein lipoylation] GO:0016746 [transferase activity, transferring acyl groups] Show all	373 aa 42.5 kDa	No	0
LIPT1-002 ENSP00000387387 ENST00000449211	C9JW10 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] Show all	135 aa 15.7 kDa	No	0
LIPT1-003 ENSP00000393591 ENST00000434566	C9JUU5 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] Show all	251 aa 28.3 kDa	No	0
LIPT1-005 ENSP00000398168 ENST00000415142	C9J6A9 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] Show all	106 aa 12.1 kDa	No	0
LIPT1-006 ENSP00000406314 ENST00000436234	C9J7C5 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.3 kDa	No	0
LIPT1-201 ENSP00000377114 ENST00000393471	Q9Y234 [Direct mapping] Lipoyltransferase 1, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0006464 [cellular protein modification process] GO:0006629 [lipid metabolic process] GO:0009249 [protein lipoylation] GO:0016746 [transferase activity, transferring acyl groups] Show all	373 aa 42.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.