Cell atlas - UBXN4 - The Human Protein Atlas

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UBXN4

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	UBXN4
Gene description	UBX domain protein 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036325
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036325	A-431	Endoplasmic reticulum
	HPA036325	U-2 OS	Cytosol
	HPA036325	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	UBXN4 (HGNC Symbol)
Synonyms	KIAA0242, UBXD2, UBXDC1
Description	UBX domain protein 4 (HGNC Symbol)
Entrez gene summary	UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q21.3
Chromosome location (bp)	135741619 - 135785055
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144224 (version 83.38)
Entrez gene	23190
UniProt	Q92575 (UniProt - Evidence at protein level)
neXtProt	NX_Q92575
Antibodypedia	UBXN4 antibodies

PROTEIN BROWSER

UBXN4-001	UBXN4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBXN4-001 ENSP00000272638 ENST00000272638	Q92575 [Direct mapping] UBX domain-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006986 [response to unfolded protein] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	508 aa 56.8 kDa	No	1
UBXN4-004 ENSP00000401748 ENST00000415164	C9JLR4 [Direct mapping] UBX domain-containing protein 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.