Expression of DLX1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Distal-less homeobox 1

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA045884

GENE INFORMATION
Gene name	DLX1
Synonyms
Description	Distal-less homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	172084740 - 172089677
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000144355 (version 83.38)
Entrez gene	1745
UniProt	P56177 (UniProt - Evidence at transcript level)
neXtProt	NX_P56177
Antibodypedia	DLX1 antibodies

PROTEIN BROWSER

DLX1-001	DLX1-002	DLX1-004	DLX1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLX1-001 ENSP00000354478 ENST00000361725	P56177 [Direct mapping] Homeobox protein DLX-1 X5D2F9 [Target identity:100%; Query identity:100%] Distal-less homeobox 1 isoform A Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009954 [proximal/distal pattern formation] GO:0021544 [subpallium development] GO:0021766 [hippocampus development] GO:0021879 [forebrain neuron differentiation] GO:0021882 [regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment] GO:0021892 [cerebral cortex GABAergic interneuron differentiation] GO:0021893 [cerebral cortex GABAergic interneuron fate commitment] GO:0030154 [cell differentiation] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045746 [negative regulation of Notch signaling pathway] GO:0048706 [embryonic skeletal system development] GO:0048715 [negative regulation of oligodendrocyte differentiation] Show all	255 aa 27.3 kDa	No	0
DLX1-002 ENSP00000341786 ENST00000341900	P56177 [Direct mapping] Homeobox protein DLX-1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0005634 [nucleus] Show all	129 aa 13.5 kDa	No	0
DLX1-004 ENSP00000448827 ENST00000469444	F8VXJ2 [Direct mapping] Homeobox protein DLX-1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	187 aa 20.5 kDa	No	0
DLX1-006 ENSP00000354865 ENST00000361609	J3KP55 [Direct mapping] Homeobox protein DLX-1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	171 aa 18.5 kDa	No	0