Expression of UBR3 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ubiquitin protein ligase E3 component n-recognin 3 (putative)

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035390

GENE INFORMATION
Gene name	UBR3 (HGNC Symbol)
Synonyms	DKFZp434P117, FLJ37422, KIAA2024, ZNF650
Description	Ubiquitin protein ligase E3 component n-recognin 3 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	169827458 - 170084131
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144357 (version 83.38)
Entrez gene	130507
UniProt	Q6ZT12 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZT12
Antibodypedia	UBR3 antibodies

PROTEIN BROWSER

UBR3-001	UBR3-007	UBR3-008	UBR3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBR3-001 ENSP00000272793 ENST00000272793	Q6ZT12 [Direct mapping] E3 ubiquitin-protein ligase UBR3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0001967 [suckling behavior] GO:0004842 [ubiquitin-protein transferase activity] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007608 [sensory perception of smell] GO:0008270 [zinc ion binding] GO:0009790 [embryo development] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	1888 aa 212.4 kDa	No	1
UBR3-007 ENSP00000389097 ENST00000439681	H7BZD8 [Direct mapping] E3 ubiquitin-protein ligase UBR3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	588 aa 67.7 kDa	No	1
UBR3-008 ENSP00000376409 ENST00000392632	H0Y3K2 [Direct mapping] E3 ubiquitin-protein ligase UBR3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0005737 [cytoplasm] GO:0016567 [protein ubiquitination] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	950 aa 107.5 kDa	Yes	1
UBR3-201 ENSP00000396068 ENST00000418381	Q6ZT12 [Direct mapping] E3 ubiquitin-protein ligase UBR3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0001701 [in utero embryonic development] GO:0001967 [suckling behavior] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007608 [sensory perception of smell] GO:0008270 [zinc ion binding] GO:0009790 [embryo development] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0042048 [olfactory behavior] GO:0061630 [ubiquitin protein ligase activity] GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway] Show all	1888 aa 212.4 kDa	No	1