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UBR3

GENERAL INFORMATION

Gene name

 UBR3

Gene description

 Ubiquitin protein ligase E3 component n-recognin 3 (putative)

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA035390
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UBR3 (HGNC Symbol)

Synonyms

 DKFZp434P117, FLJ37422, KIAA2024, ZNF650

Description

 Ubiquitin protein ligase E3 component n-recognin 3 (putative) (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 169827458 - 170084131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144357 (version 83.38)

Entrez gene

 130507

UniProt

 Q6ZT12 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6ZT12

Antibodypedia

 UBR3 antibodies

PROTEIN BROWSER
UBR3-001
UBR3-007
UBR3-008
UBR3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBR3-001
ENSP00000272793
ENST00000272793
Q6ZT12 [Direct mapping]
E3 ubiquitin-protein ligase UBR3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0001967 [suckling behavior]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007608 [sensory perception of smell]
GO:0008270 [zinc ion binding]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway]
Show all
 1888 aa
212.4 kDa 		No 1
UBR3-007
ENSP00000389097
ENST00000439681
H7BZD8 [Direct mapping]
E3 ubiquitin-protein ligase UBR3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway]
Show all
 588 aa
67.7 kDa 		No 1
UBR3-008
ENSP00000376409
ENST00000392632
H0Y3K2 [Direct mapping]
E3 ubiquitin-protein ligase UBR3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0005737 [cytoplasm]
GO:0016567 [protein ubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway]
Show all
 950 aa
107.5 kDa 		Yes 1
UBR3-201
ENSP00000396068
ENST00000418381
Q6ZT12 [Direct mapping]
E3 ubiquitin-protein ligase UBR3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0001701 [in utero embryonic development]
GO:0001967 [suckling behavior]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007608 [sensory perception of smell]
GO:0008270 [zinc ion binding]
GO:0009790 [embryo development]
GO:0016021 [integral component of membrane]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0042048 [olfactory behavior]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071596 [ubiquitin-dependent protein catabolic process via the N-end rule pathway]
Show all
 1888 aa
212.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.