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GMPPA

CANCER ATLAS

Gene description

 GDP-mannose pyrophosphorylase A

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035512
HPA035513

GENE INFORMATION

Gene name

 GMPPA

Synonyms

Description

 GDP-mannose pyrophosphorylase A (HGNC Symbol)

Entrez gene summary

 This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 219498867 - 219506989

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144591 (version 83.38)

Entrez gene

 29926

UniProt

 Q96IJ6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96IJ6

Antibodypedia

 GMPPA antibodies

PROTEIN BROWSER
GMPPA-001
GMPPA-002
GMPPA-003
GMPPA-004
GMPPA-006
GMPPA-008
GMPPA-011
GMPPA-012
GMPPA-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMPPA-001
ENSP00000315925
ENST00000313597
Q96IJ6 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
A0A024R482 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase A, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 420 aa
46.3 kDa 		No 0
GMPPA-002
ENSP00000363027
ENST00000373917
Q96IJ6 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 473 aa
52 kDa 		No 0
GMPPA-003
ENSP00000350949
ENST00000358215
Q96IJ6 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
A0A024R482 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase A, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 420 aa
46.3 kDa 		No 0
GMPPA-004
ENSP00000363016
ENST00000373908
Q96IJ6 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
A0A024R482 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase A, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 420 aa
46.3 kDa 		No 0
GMPPA-006
ENSP00000392465
ENST00000455657
C9J255 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009058 [biosynthetic process]
GO:0016779 [nucleotidyltransferase activity]
Show all
 179 aa
20 kDa 		No 0
GMPPA-008
ENSP00000411060
ENST00000435316
C9JAH0 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009058 [biosynthetic process]
GO:0016779 [nucleotidyltransferase activity]
Show all
 249 aa
28 kDa 		No 0
GMPPA-011
ENSP00000489451
ENST00000480034
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016740 [transferase activity]
Show all
 114 aa
11.8 kDa 		No 0
GMPPA-012
ENSP00000340760
ENST00000341142
Q96IJ6 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
A0A024R482 [Target identity:100%; Query identity:100%]
GDP-mannose pyrophosphorylase A, isoform CRA_a
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0009058 [biosynthetic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
Show all
 420 aa
46.3 kDa 		No 0
GMPPA-201
ENSP00000478700
ENST00000622191
A0A087WUI8 [Direct mapping]
Mannose-1-phosphate guanyltransferase alpha
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009058 [biosynthetic process]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
Show all
 399 aa
43.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.