Cell atlas - GMPPA - The Human Protein Atlas

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GMPPA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GMPPA
Gene description	GDP-mannose pyrophosphorylase A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035513
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035513	A-431	Nucleoplasm
	HPA035513	U-2 OS	Nucleoplasm
	HPA035513	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	GMPPA
Synonyms
Description	GDP-mannose pyrophosphorylase A (HGNC Symbol)
Entrez gene summary	This gene is thought to encode a GDP-mannose pyrophosphorylase. This enzyme catalyzes the reaction which converts mannose-1-phosphate and GTP to GDP-mannose which is involved in the production of N-linked oligosaccharides. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q35
Chromosome location (bp)	219498867 - 219506989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144591 (version 83.38)
Entrez gene	29926
UniProt	Q96IJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96IJ6
Antibodypedia	GMPPA antibodies

PROTEIN BROWSER

GMPPA-001	GMPPA-002	GMPPA-003	GMPPA-004	GMPPA-006	GMPPA-008	GMPPA-011	GMPPA-012	GMPPA-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GMPPA-001 ENSP00000315925 ENST00000313597	Q96IJ6 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha A0A024R482 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase A, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	420 aa 46.3 kDa	No	0
GMPPA-002 ENSP00000363027 ENST00000373917	Q96IJ6 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	473 aa 52 kDa	No	0
GMPPA-003 ENSP00000350949 ENST00000358215	Q96IJ6 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha A0A024R482 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase A, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	420 aa 46.3 kDa	No	0
GMPPA-004 ENSP00000363016 ENST00000373908	Q96IJ6 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha A0A024R482 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase A, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	420 aa 46.3 kDa	No	0
GMPPA-006 ENSP00000392465 ENST00000455657	C9J255 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009058 [biosynthetic process] GO:0016779 [nucleotidyltransferase activity] Show all	179 aa 20 kDa	No	0
GMPPA-008 ENSP00000411060 ENST00000435316	C9JAH0 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009058 [biosynthetic process] GO:0016779 [nucleotidyltransferase activity] Show all	249 aa 28 kDa	No	0
GMPPA-011 ENSP00000489451 ENST00000480034		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016740 [transferase activity] Show all	114 aa 11.8 kDa	No	0
GMPPA-012 ENSP00000340760 ENST00000341142	Q96IJ6 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha A0A024R482 [Target identity:100%; Query identity:100%] GDP-mannose pyrophosphorylase A, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0009058 [biosynthetic process] GO:0009298 [GDP-mannose biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	420 aa 46.3 kDa	No	0
GMPPA-201 ENSP00000478700 ENST00000622191	A0A087WUI8 [Direct mapping] Mannose-1-phosphate guanyltransferase alpha Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009058 [biosynthetic process] GO:0016740 [transferase activity] GO:0016779 [nucleotidyltransferase activity] Show all	399 aa 43.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.