Expression of ITGA9 in cancer - Summary

CANCER ATLAS

Gene description

Integrin, alpha 9

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030609

GENE INFORMATION
Gene name	ITGA9 (HGNC Symbol)
Synonyms	ALPHA-RLC, ITGA4L, RLC
Description	Integrin, alpha 9 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	37452115 - 37823514
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144668 (version 83.38)
Entrez gene	3680
UniProt	Q13797 (UniProt - Evidence at protein level)
neXtProt	NX_Q13797
Antibodypedia	ITGA9 antibodies

PROTEIN BROWSER

ITGA9-001	ITGA9-002	ITGA9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGA9-001 ENSP00000264741 ENST00000264741	Q13797 [Direct mapping] Integrin alpha-9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0008305 [integrin complex] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0030593 [neutrophil chemotaxis] GO:0034679 [integrin alpha9-beta1 complex] GO:0042060 [wound healing] GO:0043236 [laminin binding] GO:0046872 [metal ion binding] Show all	1035 aa 114.5 kDa	Yes	1
ITGA9-002 ENSP00000397258 ENST00000422441	E9PDS3 [Direct mapping] Integrin alpha-9 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	632 aa 69.1 kDa	Yes	0
ITGA9-004 ENSP00000406533 ENST00000411817	H7C2L1 [Direct mapping] Integrin alpha-9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8.1 kDa	No	0