Cell atlas - ITGA9 - The Human Protein Atlas

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ITGA9

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	ITGA9
Gene description	Integrin, alpha 9
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (SH-SY5Y, CACO-2, HEL, WM-115)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA030609
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, CACO-2, HEL, WM-115) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the nucleus.

Main location

Vesicles (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030609	SH-SY5Y	Vesicles
	HPA030609	U-2 OS	Nucleus
	HPA030609	U-2 OS	Vesicles

GENE INFORMATION
Gene name	ITGA9 (HGNC Symbol)
Synonyms	ALPHA-RLC, ITGA4L, RLC
Description	Integrin, alpha 9 (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	37452115 - 37823514
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144668 (version 83.38)
Entrez gene	3680
UniProt	Q13797 (UniProt - Evidence at protein level)
neXtProt	NX_Q13797
Antibodypedia	ITGA9 antibodies

PROTEIN BROWSER

ITGA9-001	ITGA9-002	ITGA9-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGA9-001 ENSP00000264741 ENST00000264741	Q13797 [Direct mapping] Integrin alpha-9 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007411 [axon guidance] GO:0008305 [integrin complex] GO:0009925 [basal plasma membrane] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0030593 [neutrophil chemotaxis] GO:0034679 [integrin alpha9-beta1 complex] GO:0042060 [wound healing] GO:0043236 [laminin binding] GO:0046872 [metal ion binding] Show all	1035 aa 114.5 kDa	Yes	1
ITGA9-002 ENSP00000397258 ENST00000422441	E9PDS3 [Direct mapping] Integrin alpha-9 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] Show all	632 aa 69.1 kDa	Yes	0
ITGA9-004 ENSP00000406533 ENST00000411817	H7C2L1 [Direct mapping] Integrin alpha-9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.