Expression of COL8A1 in cancer - Summary

CANCER ATLAS

Gene description

Collagen, type VIII, alpha 1

Protein class

Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053107

GENE INFORMATION
Gene name	COL8A1 (HGNC Symbol)
Synonyms	C3orf7, MGC9568
Description	Collagen, type VIII, alpha 1 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
Chromosome	3
Cytoband	q12.1
Chromosome location (bp)	99638475 - 99799226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144810 (version 83.38)
Entrez gene	1295
UniProt	P27658 (UniProt - Evidence at protein level)
neXtProt	NX_P27658
Antibodypedia	COL8A1 antibodies

PROTEIN BROWSER

COL8A1-001	COL8A1-003	COL8A1-007	COL8A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL8A1-001 ENSP00000261037 ENST00000261037	P27658 [Direct mapping] Collagen alpha-1(VIII) chain Vastatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005591 [collagen type VIII trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0048593 [camera-type eye morphogenesis] GO:0050673 [epithelial cell proliferation] GO:0070062 [extracellular exosome] Show all	744 aa 73.4 kDa	Yes	0
COL8A1-003 ENSP00000387589 ENST00000452013	C9JTN9 [Direct mapping] Collagen alpha-1(VIII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12.5 kDa	Yes	0
COL8A1-007 ENSP00000482679 ENST00000621757	A0A087WZI0 [Direct mapping] Collagen alpha-1(VIII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 20.9 kDa	Yes	0
COL8A1-201 ENSP00000273342 ENST00000273342	P27658 [Direct mapping] Collagen alpha-1(VIII) chain Vastatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005591 [collagen type VIII trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] Show all	744 aa 73.4 kDa	Yes	0