Cell atlas - COL8A1 - The Human Protein Atlas

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COL8A1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	COL8A1
Gene description	Collagen, type VIII, alpha 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (TIME, LHCN-M2, WM-115, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (supported)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA053107
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME, LHCN-M2, WM-115, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053107	HeLa	Vesicles
	HPA053107	U-2 OS	Vesicles
	HPA053107	U-251 MG	Vesicles

MOUSE CELLS

Main location

Vesicles

Mouse gene

ENSMUSG00000068196 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053107	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	COL8A1 (HGNC Symbol)
Synonyms	C3orf7, MGC9568
Description	Collagen, type VIII, alpha 1 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Dec 2011]
Chromosome	3
Cytoband	q12.1
Chromosome location (bp)	99638475 - 99799226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144810 (version 83.38)
Entrez gene	1295
UniProt	P27658 (UniProt - Evidence at protein level)
neXtProt	NX_P27658
Antibodypedia	COL8A1 antibodies

PROTEIN BROWSER

COL8A1-001	COL8A1-003	COL8A1-007	COL8A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL8A1-001 ENSP00000261037 ENST00000261037	P27658 [Direct mapping] Collagen alpha-1(VIII) chain Vastatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005591 [collagen type VIII trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0048593 [camera-type eye morphogenesis] GO:0050673 [epithelial cell proliferation] GO:0070062 [extracellular exosome] Show all	744 aa 73.4 kDa	Yes	0
COL8A1-003 ENSP00000387589 ENST00000452013	C9JTN9 [Direct mapping] Collagen alpha-1(VIII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12.5 kDa	Yes	0
COL8A1-007 ENSP00000482679 ENST00000621757	A0A087WZI0 [Direct mapping] Collagen alpha-1(VIII) chain Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		202 aa 20.9 kDa	Yes	0
COL8A1-201 ENSP00000273342 ENST00000273342	P27658 [Direct mapping] Collagen alpha-1(VIII) chain Vastatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005591 [collagen type VIII trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007155 [cell adhesion] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] Show all	744 aa 73.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.