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Moderate to strong cytoplasmic positivity with a granular pattern was observed in most testicular-, liver-, lung- and colorectal cancers and in a few cases of other tumor types.
GENE INFORMATION
Gene name
ADPRH (HGNC Symbol)
Synonyms
ARH1
Description
ADP-ribosylarginine hydrolase (HGNC Symbol)
Entrez gene summary
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0051725 [protein de-ADP-ribosylation]
