Cell atlas - ADPRH - The Human Protein Atlas

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ADPRH

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ADPRH
Gene description	ADP-ribosylarginine hydrolase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear membrane. In addition localized to the nucleus.
RNA cell category	Cell line enhanced (HDLM-2, U-266/70, Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear membrane (approved)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036961
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, U-266/70, Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear membrane. In addition localized to the nucleus.

Main location

Nuclear membrane (approved)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036961	PC-3	Nucleus
	HPA036961	PC-3	Nuclear membrane
	HPA036961	RH-30	Nucleus
	HPA036961	RH-30	Nuclear membrane
	HPA036961	U-2 OS	Nucleus
	HPA036961	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	ADPRH (HGNC Symbol)
Synonyms	ARH1
Description	ADP-ribosylarginine hydrolase (HGNC Symbol)
Entrez gene summary	The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Chromosome	3
Cytoband	q13.33
Chromosome location (bp)	119579268 - 119589945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144843 (version 83.38)
Entrez gene	141
UniProt	P54922 (UniProt - Evidence at protein level)
neXtProt	NX_P54922
Antibodypedia	ADPRH antibodies

PROTEIN BROWSER

ADPRH-001	ADPRH-003	ADPRH-004	ADPRH-005	ADPRH-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADPRH-001 ENSP00000420200 ENST00000478399	P54922 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0051725 [protein de-ADP-ribosylation] Show all	357 aa 39.5 kDa	No	0
ADPRH-003 ENSP00000417528 ENST00000478927	P54922 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0051725 [protein de-ADP-ribosylation] Show all	357 aa 39.5 kDa	No	0
ADPRH-004 ENSP00000349496 ENST00000357003	P54922 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0051725 [protein de-ADP-ribosylation] Show all	357 aa 39.5 kDa	No	0
ADPRH-005 ENSP00000417430 ENST00000465513	P54922 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0003875 [ADP-ribosylarginine hydrolase activity] GO:0005515 [protein binding] GO:0006464 [cellular protein modification process] GO:0051725 [protein de-ADP-ribosylation] Show all	357 aa 39.5 kDa	No	0
ADPRH-008 ENSP00000419703 ENST00000481816	C9JZW7 [Direct mapping] [Protein ADP-ribosylarginine] hydrolase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.