Cell atlas - BOC - The Human Protein Atlas

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BOC

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	BOC
Gene description	BOC cell adhesion associated, oncogene regulated
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & nucleoplasm.
RNA cell category	Cell line enhanced (AN3-CA, BJ hTERT+, AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Plasma membrane (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 3 antibodies. CAB025806 , HPA060778 , HPA061787
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, BJ hTERT+, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & nucleoplasm.

Main location

Nucleoplasm (supported), Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB025806	A-431	Nucleoplasm
			Nuclear bodies
			Plasma membrane
	CAB025806	U-2 OS	Nucleoplasm
			Nuclear bodies
			Plasma membrane
	CAB025806	U-251 MG	Nucleoplasm
			Nuclear bodies
			Plasma membrane
	HPA060778	A549	Nucleoplasm
	HPA060778	RH-30	Nucleoplasm
	HPA060778	U-2 OS	Nucleoplasm
	HPA061787	A549	Nucleoplasm
	HPA061787	RH-30	Nucleoplasm
	HPA061787	U-2 OS	Nucleoplasm	Intensity

GENE INFORMATION
Gene name	BOC (HGNC Symbol)
Synonyms	CDON2
Description	BOC cell adhesion associated, oncogene regulated (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Chromosome	3
Cytoband	q13.2
Chromosome location (bp)	113211003 - 113287459
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144857 (version 83.38)
Entrez gene	91653
UniProt	Q9BWV1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWV1
Antibodypedia	BOC antibodies

PROTEIN BROWSER

BOC-001	BOC-002	BOC-003	BOC-004	BOC-008	BOC-009	BOC-010	BOC-011	BOC-016	BOC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BOC-001 ENSP00000418663 ENST00000495514	Q9BWV1 [Direct mapping] Brother of CDO Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0042692 [muscle cell differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1114 aa 121.1 kDa	Yes	1
BOC-002 ENSP00000420154 ENST00000485230	Q96DN7 [Direct mapping] BOC protein; Boc homolog (Mouse), isoform CRA_b; Brother of CDO; cDNA FLJ31797 fis, clone NT2RI2008942, weakly similar to NEURAL CELL ADHESION MOLECULE L1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 16.3 kDa	Yes	0
BOC-003 ENSP00000273395 ENST00000273395	Q9BWV1 [Direct mapping] Brother of CDO Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0042692 [muscle cell differentiation] GO:0044295 [axonal growth cone] GO:0045663 [positive regulation of myoblast differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1115 aa 121.2 kDa	Yes	1
BOC-004 ENSP00000417337 ENST00000484034	Q96DN7 [Direct mapping] BOC protein; Boc homolog (Mouse), isoform CRA_b; Brother of CDO; cDNA FLJ31797 fis, clone NT2RI2008942, weakly similar to NEURAL CELL ADHESION MOLECULE L1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 16.3 kDa	Yes	0
BOC-008 ENSP00000417362 ENST00000464546	C9J2L7 [Direct mapping] Brother of CDO Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	85 aa 9 kDa	Yes	0
BOC-009 ENSP00000418118 ENST00000462425	C9J9M5 [Direct mapping] Brother of CDO Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.5 kDa	No	0
BOC-010 ENSP00000418260 ENST00000494687	C9J7V2 [Direct mapping] Brother of CDO Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.5 kDa	Yes	0
BOC-011 ENSP00000419022 ENST00000498710	C9JZ38 [Direct mapping] Brother of CDO Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7.3 kDa	No	0
BOC-016 ENSP00000418182 ENST00000473008	H7C4U8 [Direct mapping] Brother of CDO Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.1 kDa	No	0
BOC-201 ENSP00000347546 ENST00000355385	Q9BWV1 [Direct mapping] Brother of CDO Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0042692 [muscle cell differentiation] GO:0045663 [positive regulation of myoblast differentiation] GO:0051149 [positive regulation of muscle cell differentiation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	1114 aa 121.1 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.