Expression of SRPRB in cancer - Summary

CANCER ATLAS

Gene description

Signal recognition particle receptor, B subunit

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA011173

GENE INFORMATION
Gene name	SRPRB (HGNC Symbol)
Synonyms	APMCF1
Description	Signal recognition particle receptor, B subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	133784033 - 133825772
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144867 (version 83.38)
Entrez gene	58477
UniProt	Q9Y5M8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5M8
Antibodypedia	SRPRB antibodies

PROTEIN BROWSER

SRPRB-001	SRPRB-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRPRB-001 ENSP00000418401 ENST00000466490	Q9Y5M8 [Direct mapping] Signal recognition particle receptor subunit beta Q549N5 [Target identity:100%; Query identity:100%] Signal recognition particle receptor beta subunit; Signal recognition particle receptor, B subunit, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005525 [GTP binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005881 [cytoplasmic microtubule] GO:0006412 [translation] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0007264 [small GTPase mediated signal transduction] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0044267 [cellular protein metabolic process] Show all	271 aa 29.7 kDa	No	1
SRPRB-003 ENSP00000417096 ENST00000484684	C9J5Z8 [Direct mapping] Signal recognition particle receptor subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	92 aa 10 kDa	No	1