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SRPRB

GENERAL INFORMATION

Gene name

 SRPRB

Gene description

 Signal recognition particle receptor, B subunit

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA011173
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SRPRB (HGNC Symbol)

Synonyms

 APMCF1

Description

 Signal recognition particle receptor, B subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q22.1

Chromosome location (bp)

 133784033 - 133825772

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144867 (version 83.38)

Entrez gene

 58477

UniProt

 Q9Y5M8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5M8

Antibodypedia

 SRPRB antibodies

PROTEIN BROWSER
SRPRB-001
SRPRB-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRPRB-001
ENSP00000418401
ENST00000466490
Q9Y5M8 [Direct mapping]
Signal recognition particle receptor subunit beta
Q549N5 [Target identity:100%; Query identity:100%]
Signal recognition particle receptor beta subunit; Signal recognition particle receptor, B subunit, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005881 [cytoplasmic microtubule]
GO:0006412 [translation]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
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 271 aa
29.7 kDa 		No 1
SRPRB-003
ENSP00000417096
ENST00000484684
C9J5Z8 [Direct mapping]
Signal recognition particle receptor subunit beta
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 92 aa
10 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.