Expression of EIF2A in cancer - Summary

CANCER ATLAS

Gene description

Eukaryotic translation initiation factor 2A, 65kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036256

GENE INFORMATION
Gene name	EIF2A (HGNC Symbol)
Synonyms	EIF-2A
Description	Eukaryotic translation initiation factor 2A, 65kDa (HGNC Symbol)
Entrez gene summary	EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	150546678 - 150584242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144895 (version 83.38)
Entrez gene	83939
UniProt	Q9BY44 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY44
Antibodypedia	EIF2A antibodies

PROTEIN BROWSER

EIF2A-001	EIF2A-002	EIF2A-003	EIF2A-004	EIF2A-010	EIF2A-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2A-001 ENSP00000417229 ENST00000460851	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0009967 [positive regulation of signal transduction] GO:0032933 [SREBP signaling pathway] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	585 aa 65 kDa	No	0
EIF2A-002 ENSP00000420537 ENST00000487799	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	560 aa 62.3 kDa	No	0
EIF2A-003 ENSP00000385292 ENST00000406576	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	524 aa 58 kDa	No	0
EIF2A-004 ENSP00000273435 ENST00000273435	F8WAE5 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0006413 [translational initiation] Show all	580 aa 64.4 kDa	No	0
EIF2A-010 ENSP00000418698 ENST00000482093	C9IZE1 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		237 aa 26.1 kDa	No	0
EIF2A-015 ENSP00000420611 ENST00000465535	H7C5R5 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		316 aa 35.2 kDa	No	0