Cell atlas - EIF2A - The Human Protein Atlas

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EIF2A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	EIF2A
Gene description	Eukaryotic translation initiation factor 2A, 65kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036256
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & mitochondria.

Main location

Mitochondria (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036256	A-431	Mitochondria	Intensity
	HPA036256	U-2 OS	Mitochondria	Intensity
	HPA036256	U-251 MG	Cytosol

GENE INFORMATION
Gene name	EIF2A (HGNC Symbol)
Synonyms	EIF-2A
Description	Eukaryotic translation initiation factor 2A, 65kDa (HGNC Symbol)
Entrez gene summary	EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	150546678 - 150584242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144895 (version 83.38)
Entrez gene	83939
UniProt	Q9BY44 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY44
Antibodypedia	EIF2A antibodies

PROTEIN BROWSER

EIF2A-001	EIF2A-002	EIF2A-003	EIF2A-004	EIF2A-010	EIF2A-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2A-001 ENSP00000417229 ENST00000460851	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0006468 [protein phosphorylation] GO:0009967 [positive regulation of signal transduction] GO:0032933 [SREBP signaling pathway] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	585 aa 65 kDa	No	0
EIF2A-002 ENSP00000420537 ENST00000487799	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	560 aa 62.3 kDa	No	0
EIF2A-003 ENSP00000385292 ENST00000406576	Q9BY44 [Direct mapping] Eukaryotic translation initiation factor 2A Eukaryotic translation initiation factor 2A, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0042255 [ribosome assembly] GO:0043022 [ribosome binding] GO:0072562 [blood microparticle] Show all	524 aa 58 kDa	No	0
EIF2A-004 ENSP00000273435 ENST00000273435	F8WAE5 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003743 [translation initiation factor activity] GO:0006413 [translational initiation] Show all	580 aa 64.4 kDa	No	0
EIF2A-010 ENSP00000418698 ENST00000482093	C9IZE1 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		237 aa 26.1 kDa	No	0
EIF2A-015 ENSP00000420611 ENST00000465535	H7C5R5 [Direct mapping] Eukaryotic translation initiation factor 2A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		316 aa 35.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.