Expression of AMT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Aminomethyltransferase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA005566

GENE INFORMATION
Gene name	AMT (HGNC Symbol)
Synonyms	GCST, NKH
Description	Aminomethyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49416778 - 49422753
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145020 (version 83.38)
Entrez gene	275
UniProt	P48728 (UniProt - Evidence at protein level)
neXtProt	NX_P48728
Antibodypedia	AMT antibodies

PROTEIN BROWSER

AMT-003	AMT-005	AMT-006	AMT-013	AMT-201	AMT-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMT-003 ENSP00000273588 ENST00000273588	P48728 [Direct mapping] Aminomethyltransferase, mitochondrial A0A024R2U7 [Target identity:100%; Query identity:100%] Aminomethyltransferase Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004047 [aminomethyltransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006546 [glycine catabolic process] GO:0008483 [transaminase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] Show all	403 aa 43.9 kDa	No	0
AMT-005 ENSP00000403821 ENST00000427987	H0Y695 [Direct mapping] Aminomethyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004047 [aminomethyltransferase activity] GO:0006546 [glycine catabolic process] GO:0008483 [transaminase activity] GO:0032259 [methylation] Show all	384 aa 41.4 kDa	No	0
AMT-006 ENSP00000415619 ENST00000458307	P48728 [Direct mapping] Aminomethyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004047 [aminomethyltransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006546 [glycine catabolic process] GO:0008483 [transaminase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] Show all	359 aa 39.3 kDa	No	0
AMT-013 ENSP00000388068 ENST00000430521	C9JXJ4 [Direct mapping] Aminomethyltransferase, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		262 aa 28.1 kDa	No	0
AMT-201 ENSP00000378747 ENST00000395338	P48728 [Direct mapping] Aminomethyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004047 [aminomethyltransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006546 [glycine catabolic process] GO:0008483 [transaminase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] Show all	386 aa 41.8 kDa	No	0
AMT-202 ENSP00000443200 ENST00000538581	P48728 [Direct mapping] Aminomethyltransferase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004047 [aminomethyltransferase activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006546 [glycine catabolic process] GO:0008483 [transaminase activity] GO:0032259 [methylation] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0046487 [glyoxylate metabolic process] Show all	347 aa 37.4 kDa	No	0