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AMT

GENERAL INFORMATION

Gene name

 AMT

Gene description

 Aminomethyltransferase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression with granular pattern at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA005566
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 AMT (HGNC Symbol)

Synonyms

 GCST, NKH

Description

 Aminomethyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 49416778 - 49422753

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145020 (version 83.38)

Entrez gene

 275

UniProt

 P48728 (UniProt - Evidence at protein level)

neXtProt

 NX_P48728

Antibodypedia

 AMT antibodies

PROTEIN BROWSER
AMT-003
AMT-005
AMT-006
AMT-013
AMT-201
AMT-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMT-003
ENSP00000273588
ENST00000273588
P48728 [Direct mapping]
Aminomethyltransferase, mitochondrial
A0A024R2U7 [Target identity:100%; Query identity:100%]
Aminomethyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004047 [aminomethyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006546 [glycine catabolic process]
GO:0008483 [transaminase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046487 [glyoxylate metabolic process]
Show all
 403 aa
43.9 kDa 		No 0
AMT-005
ENSP00000403821
ENST00000427987
H0Y695 [Direct mapping]
Aminomethyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004047 [aminomethyltransferase activity]
GO:0006546 [glycine catabolic process]
GO:0008483 [transaminase activity]
GO:0032259 [methylation]
Show all
 384 aa
41.4 kDa 		No 0
AMT-006
ENSP00000415619
ENST00000458307
P48728 [Direct mapping]
Aminomethyltransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004047 [aminomethyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006546 [glycine catabolic process]
GO:0008483 [transaminase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046487 [glyoxylate metabolic process]
Show all
 359 aa
39.3 kDa 		No 0
AMT-013
ENSP00000388068
ENST00000430521
C9JXJ4 [Direct mapping]
Aminomethyltransferase, mitochondrial
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 262 aa
28.1 kDa 		No 0
AMT-201
ENSP00000378747
ENST00000395338
P48728 [Direct mapping]
Aminomethyltransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004047 [aminomethyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006546 [glycine catabolic process]
GO:0008483 [transaminase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046487 [glyoxylate metabolic process]
Show all
 386 aa
41.8 kDa 		No 0
AMT-202
ENSP00000443200
ENST00000538581
P48728 [Direct mapping]
Aminomethyltransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004047 [aminomethyltransferase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006546 [glycine catabolic process]
GO:0008483 [transaminase activity]
GO:0032259 [methylation]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046487 [glyoxylate metabolic process]
Show all
 347 aa
37.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.