Fields »
ABOUT
HELP
BLOG
EIF2B5

CANCER ATLAS

Gene description

 Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB015412

GENE INFORMATION

Gene name

 EIF2B5 (HGNC Symbol)

Synonyms

 EIF-2B, EIF2Bepsilon

Description

 Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Chromosome

 3

Cytoband

 q27.1

Chromosome location (bp)

 184135038 - 184684758

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145191 (version 83.38)

Entrez gene

 8893

UniProt

 Q13144 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13144

Antibodypedia

 EIF2B5 antibodies

PROTEIN BROWSER
EIF2B5-001
EIF2B5-003
EIF2B5-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2B5-001
ENSP00000273783
ENST00000273783
Q13144 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0007568 [aging]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014002 [astrocyte development]
GO:0014003 [oligodendrocyte development]
GO:0031369 [translation initiation factor binding]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035690 [cellular response to drug]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0045948 [positive regulation of translational initiation]
GO:0048708 [astrocyte differentiation]
Show all
 721 aa
80.4 kDa 		No 0
EIF2B5-003
ENSP00000414775
ENST00000432569
C9JRD9 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 107 aa
11.2 kDa 		No 0
EIF2B5-017
ENSP00000409142
ENST00000444495
E9PC74 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
 705 aa
78.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.