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Most malignant tissues were negative. A few cases of breast and renal cancers showed moderate cytoplasmic staining. Plasma was distinctly stained.
GENE INFORMATION
Gene name
AHSG (HGNC Symbol)
Synonyms
A2HS, FETUA, HSGA
Description
Alpha-2-HS-glycoprotein (HGNC Symbol)
Entrez gene summary
Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
P02765 [Direct mapping] Alpha-2-HS-glycoprotein Alpha-2-HS-glycoprotein chain A Alpha-2-HS-glycoprotein chain B
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006907 [pinocytosis] GO:0006953 [acute-phase response] GO:0010951 [negative regulation of endopeptidase activity] GO:0019210 [kinase inhibitor activity] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0042326 [negative regulation of phosphorylation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050766 [positive regulation of phagocytosis] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle]
