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DGKQ

GENERAL INFORMATION

Gene name

 DGKQ

Gene description

 Diacylglycerol kinase, theta 110kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA026797 , CAB033835
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DGKQ (HGNC Symbol)

Synonyms

 DAGK, DAGK4, DAGK7

Description

 Diacylglycerol kinase, theta 110kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 958887 - 986895

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145214 (version 83.38)

Entrez gene

 1609

UniProt

 P52824 (UniProt - Evidence at protein level)

neXtProt

 NX_P52824

Antibodypedia

 DGKQ antibodies

PROTEIN BROWSER
DGKQ-001
DGKQ-002
DGKQ-003
DGKQ-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGKQ-001
ENSP00000273814
ENST00000273814
P52824 [Direct mapping]
Diacylglycerol kinase theta
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Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016607 [nuclear speck]
GO:0019900 [kinase binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030168 [platelet activation]
GO:0033198 [response to ATP]
GO:0033613 [activating transcription factor binding]
GO:0035556 [intracellular signal transduction]
GO:0043274 [phospholipase binding]
GO:0046872 [metal ion binding]
GO:0070493 [thrombin receptor signaling pathway]
GO:0070528 [protein kinase C signaling]
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 942 aa
101.2 kDa 		No 0
DGKQ-002
ENSP00000425862
ENST00000509465
H0YA20 [Direct mapping]
Diacylglycerol kinase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
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 876 aa
94.8 kDa 		No 0
DGKQ-003
ENSP00000427268
ENST00000510286
D6RJB4 [Direct mapping]
Diacylglycerol kinase theta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
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 143 aa
16.3 kDa 		No 0
DGKQ-005
ENSP00000421756
ENST00000515182
H0Y8Q7 [Direct mapping]
Diacylglycerol kinase theta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004143 [diacylglycerol kinase activity]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016310 [phosphorylation]
Show all
 157 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.