Expression of TRMT10A in cancer - Summary

CANCER ATLAS

Gene description

TRNA methyltransferase 10A

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047601

GENE INFORMATION
Gene name	TRMT10A (HGNC Symbol)
Synonyms	MGC27034, RG9MTD2, TRM10
Description	TRNA methyltransferase 10A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99546709 - 99564032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145331 (version 83.38)
Entrez gene	93587
UniProt	Q8TBZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBZ6
Antibodypedia	TRMT10A antibodies

PROTEIN BROWSER

TRMT10A-001	TRMT10A-002	TRMT10A-003	TRMT10A-004	TRMT10A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRMT10A-001 ENSP00000378343 ENST00000394877	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-002 ENSP00000378342 ENST00000394876	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-003 ENSP00000273962 ENST00000273962	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-004 ENSP00000423628 ENST00000514547	D6R954 [Direct mapping] tRNA methyltransferase 10 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		200 aa 24 kDa	No	0
TRMT10A-005 ENSP00000397551 ENST00000455368	X6REK4 [Direct mapping] tRNA methyltransferase 10 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		206 aa 24.6 kDa	No	0